Experimental status epilepticus in animals: What are we modeling?

Status epilepticus: For what are we waiting?

What is nonconvulsive status epilepticus, and what are its subtypes?

Prolonged nonconvulsive seizures have been recognized at least since the 19th century, although their inclusion within the rubric of status epilepticus was only formalized by Gastaut and colleagues after the Xth Marseilles Colloquium, held in 1962 (Gastaut et al., 1967). This was the first ever large meeting devoted to the topic of status epilepticus, and the concept that there were status form...

Treatment of status epilepticus with ketamine, are we there yet?

Status epilepticus (SE), a neurological emergency both in adults and in children, could lead to brain damage and even death if untreated. Generalized convulsive SE (GCSE) is the most common and severe form, an example of which is that induced by organophosphorus nerve agents. First- and second-line pharmacotherapies are relatively consensual, but if seizures are still not controlled, there is c...

Consequences of status epilepticus in the intensive care unit: what we know and what we need to know.

Commentary By definition, critically ill patients are expected to have a complex clinical picture, with multiple immediate life-threatening concerns ranging from major systemic dysfunctions to devastating acute neurological injuries. So, in the extreme environment of an intensive care unit (ICU), survival is the goal and seizures/status epilepticus represent " yet another problem " to rule out ...

What Are We Modeling When We Model Emotion?

The past 15 years have witnessed a rapid growth in computational modeling of emotion and cognitiveaffective architectures. Architectures are being built both to elucidate mechanisms of emotions, and to enhance believability and effectiveness of synthetic agents and robots. Yet in spite of the many emotion models developed to date, there is a lack of consistency, and clarity, regarding what exac...